Global Tangential Flow Filtration Market to Grow at a CAGR of 13.15% by 2030

The global tangential flow filtration market size was worth around USD 1.83 Billion in 2021 and is projected to grow around USD 4.12 Billion by 2030, with a compounded annual growth rate (CAGR) of roughly 13.15% from 2022 to 2030.

Tangential Flow Filtration (TFF), also called crossflow filtration, is a rapid and effective method undertaken for the separation and purification of media in various biopharmaceutical and food processes. Tangential flow filtration is extensively applied in diafiltration and concentration processes. This filtration is quite different from other forms of filtration, where media is passed through a membrane. As the name ‘cross-flow’ suggests, media is passed tangentially to the filter which allows a harmonious flow. When the permeate is collected, the retentive is then faintly cycled through. Tangential flow filtration when used as a prime filtration method, not only gives reliable results but also secures both the collected permeate and the filtered media.

The demand for the global tangential flow filtration market is expected to surge due to an increase in the adoption of single-use technologies among various biopharmaceutical companies and research & government institutes due to the impeccable perks it provides. Effective use of single-use technologies reduces process time, cleaning requirements, and cross-contamination, and ensures flexibility. In addition, single-use technologies play a major role in reducing footprint which further drives the growth of the market.

In addition, the extensive application of tangential flow filtration in numerous biological branches such as protein chemistry, biochemistry, molecular biology, immunology, and microbiology further creates ample opportunities for the growth of the tangential flow filtration industry. Furthermore, the rising trend toward the commercialization of recombinant proteins in the pharmaceutical industry expands the growth opportunities for the industry. On the other hand, the requirement of high capital expenditure to create and set up new production facilities and the presence of strict rules & regulations from the government restrict the growth of the market to an extent.

The global tangential flow filtration market is segmented based on product, material type, technique, application, end-user, and region.

Based on application, the global market is bifurcated into bioprocess applications, protein purification, viral vector and vaccine purification, and other applications. The protein purification segment held the largest market share in 2021, holding over 24.8% of the global market share. The major reason for the growth of this segment is the ever-growing industry of recombinant proteins. There has been a remarkable surge in the production of therapeutic proteins that drives the growth of the segment. Moreover, increased use of this separation technology to desalt & concentrate proteins & peptides and rapid adoption of recombinant protein-based therapeutics will drive the growth of the segment during the forecast period.

Based on end-user, the global market is segmented into pharmaceutical and biotechnology. The pharmaceutical and biotechnology companies segment held the largest market share in 2021, holding over 40.2% of the global market. The reason for the growth of this segment is mainly attributed to a rise in drug discovery programs, increase in expenditure and investments by companies to reach essential R&D targets, presence of various therapeutic product pipelines. In addition, numerous applications of TFF in the recovery of viral vectors, cell harvesting, broths clarification, and others are expected to drive the growth of the segment during the forecast period. Furthermore, production of COVID-19 vaccines by pharmaceutical and biotechnological companies significantly contributed to the growth of the segment.

Geographically, in the global tangential flow filtration market, the North American market accounted for the highest share, occupying more than 40.23% of the global market share, and is expected to continue this pattern during the forecast period. The main reason favoring the growth of the tangential flow filtration market in this region is the presence of modern biopharmaceutical manufacturing facilities and growth in bioprocessing operations to deliver the constant need for biotherapeutics among people. In addition, gradual rise in the number of drug development projects, a surge in the number of cases of genetic disorders and chronic diseases, an increase in awareness about the safety of treatments, remarkable expenditure on research & development activities, and the prevalence of advanced healthcare infrastructure in this region augment the growth of the market in this region.

This review is based on a report by Zion Market Research, titled “Tangential Flow Filtration Market, By Product (Single-Use Systems, Re-Usable Systems, Membrane Filter, and Accessories), By Material Type (PES/PS, Regenerated Cellulose, and Others), Technique (Ultrafiltration, Microfiltration, and Others), By Application (Bioprocess Applications, Protein Purification, Viral Vector and Vaccine Purification, and Other Applications), By End User (Pharma, Biotech) and By Region - Global and Regional Industry Overview, Market Intelligence, Comprehensive Analysis, Historical Data, and Forecasts 2022 – 2030.”- Report at https://www.zionmarketresearch.com/report/tangential-flow-filtration-market

Recent Developments:

• In September 2021, ABEC, a dominant player that delivers single-use integrated solutions & services for biopharmaceutical manufacturing, announced the launch of their new TFF system called Custom Single Run (CSR) Tangential Flow Filtration (TFF) systems, in order to appreciably expand downstream productivity for their bioprocess customers. Brady Cole, the VP of Equipment Solutions at ABEC, mentioned in a statement that traditional single-use TFF systems are cramped to a much lower flow rate so as to avoid bursting. But their CSR TFF having flow rates of more than 240 liters per minute, makes process times shorter to attain high product concentrations.
• In July 2021, Pall Corporation, a US-based dominant supplier of filtration, separations, and purification products, announced the launch of its next-generation tangential flow filtration (TFF) solution called Minimate EVO TFF system. This revolutionary system is specially designed to provide better reproducibility, productivity, and control when compared to stirred-cell technologies. The Minimate system from Pall Corporation is designed for extremely dependable buffer exchange or protein concentration for samples up to 1 liter. This innovative solution envisions streamlining desalting, laboratory-scale concentration, and buffer exchange workflows.

The global tangential flow filtration market is dominated by players such as:

• Danaher Corporation
• Sartorius AG
• Parker-Hannifin Corporation
• Alfa Laval AG
• Merck KGaA
• Repligen Corporation
• ABEC Inc.
• Sterlitech Corporation
• Synder Filtration Inc.
• Meissner Filtration Products Inc.
• Sartorius AG
• Danaher Corporation

The global tangential flow filtration market is segmented as follows:

By Product

• Single-Use Systems
• Re-Usable Systems
• Membrane Filter
• Accessories

By Material Type

• PES/PS
• Regenerated Cellulose
• Others

By Technique

• Ultrafiltration
• Microfiltration
• Others

By Application

• Bioprocess Applications
• Viral Vector and Vaccine Purification
• Other Applications

By End User

• Pharma
• Biotech

By Region

• North America
  • The U.S.
  • Canada
• Europe
  • France
  • The UK
  • Spain
  • Germany
  • Italy
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • GCC
  • South Africa
  • Rest of Middle East & Africa

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