Charcot-Marie-Tooth Disease Type I (CMT) Market Size, Share, Trends, Growth and Forecast 2032

Charcot-Marie-Tooth Disease Type I (CMT) Market Insights

Zion Market Research has published a report on the global Charcot-Marie-Tooth Disease Type I (CMT) Market, estimating its value at USD 671.4 Million in 2023, with projections indicating that it will reach USD 1168.71 Million by 2032. The market is expected to expand at a compound annual growth rate (CAGR) of 5.7% over the forecast period 2024-2032.

The report explores the factors fueling market growth, the hitches that could hamper this expansion, and the opportunities that may arise in the Charcot-Marie-Tooth Disease Type I (CMT) Market industry. Additionally, it offers a detailed analysis of how these elements will affect market demand dynamics and market performance throughout the forecast period.

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Charcot-Marie-Tooth Disease Type I (CMT) Market Size & Overview

Charcot-Marie-Tooth disease (CMT) is a disease that affects and damages the peripheral nerves that function as a transmit information and signals from the brain and spinal cord to and from the rest of the body, as well as sensory information such as touch back to the spinal cord and brain. CMT can also directly harm the nerves that control the muscles. Increasing muscle weakness thus becomes noticeable in adolescence or early adulthood, but certain types of disease can occur at any age. As the longer nerves are affected first, symptoms normally begin in the feet and lower legs and later can affect the fingers, hands, and arms. Most people with CMT have some amount of physical disability.

COVID-19 Impact Analysis

It’s been more than a year now, the COVID-19 outbreak was encountered globally and during this time, the world has suffered through unprecedented COVID-19 outbreak, several times, posing social, health, and economic emergency. Physical therapy, disease treatment, and research and development activities are some of the severely affected areas of healthcare R&D and Charcot Marie Tooth Disease Type 1A market due to COVID-19 outbreak. With travel, transport, and import-export restrictions on board and ban on local movement, people were stuck at places from where they couldn’t attend laboratories and offices for months which has made vaccine production and supply chain companies to lose enormous revenue in first 3 quarters of 2020. Research & development activities across healthcare sector have suffered enormous backlash due to stoppage of supply of raw materials for research and development and manufacturing. Investments in the animal welfare and vaccination programs and healthcare development, were held or pulled out, causing severe financial tensions.

Growth Factors

CMT1A is a very rare type of neuromuscular disorder for which drug therapy is in development phase and clinical stage and currently there is unavailability of precise drug therapy. General therapy including physical therapy and occupational therapy is highly adopted for symptom management of CMT1A. General physical therapy is inexpensive in nature, physiotherapists are widely available, and medical devices and braces are used in physical therapy, which makes it highly effective in treating symptoms and pain management in CMT1A. Over the next few years, overall market for physical therapy segment for CMT1A treatment is expected to grow exponentially

Moreover, number of drug therapies are in development and preclinical stage, which are expected to launch at the start of next decade. With these launches, initially the overall market will grow exponentially as drug therapy rates will decline due to increasing competition in market and drug therapy adoption will increase.

Charcot-Marie-Tooth Disease Type I (CMT) Market: Report Scope

Type Segment Analysis Preview

PXT3003 by Pharnext segment held a share of around 77% in 2020. This is attributable as these therapies will be one of the first to hit the global market, where initially they will be launched in North America and Europe. These drug therapies are precise in nature and treat CMT1A disease. But on the other hand, these therapies are expected to be highly expensive in nature, due to which a minimal number of patients would be able to afford it. Other patients will have to rely on medical insurances to get treated with such precise therapies. Market for these drug therapies is expected to grow exponentially from the mid of this decade.

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Therapy Industry Segment Analysis Preview

Physical therapy segment will grow at a CAGR of over 41.97% from 2021 to 2028. This is attributable Currently, physical therapy, occupational therapy, and other therapies are used for treating symptoms of CMT1A disease. In other therapies, pain management is the most widely used physical therapy, which provides great relief to patients. General physical exercises, braces, and orthopedic medical devices are also used in treatment of symptoms of CMT1A. Precise medical devices and braces are in development to be used during physical therapy sessions, which is expected to drive the overall physical therapy segments.

Regional Analysis Preview

North America region held a share of  5.7% from 2024 to 2032. This is attributable to the presence of top companies such as The National Institutes of Health, among others. Moreover, the increasing usage of therapies is expected to generate huge demand for the market in this region.

The Europe region is projected to grow at a CAGR of 26.29% over the forecast period. Whichever therapies are currently adopted for treatment are general physiotherapy techniques which also includes use of physical therapy medical devices and orthopaedic braces. Clinical trials for drug therapies are not yet conducted in few of the regions including Asia Pacific, the Middle East, & Africa, which has given a way to the physical therapies to be adopted by the patients on large scale. Adoption for such physical therapies is at greater level in these regions, driving the physical therapy treatment market for CMT1A.

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Key Market Players & Competitive Landscape

Some of key players in the Charcot-Marie-Tooth Disease Type I market are 

• Acceleron Pharma
• Genzyme (A Sanofi Company)
• Inflectis Bioscience
• Ionis Pharmaceuticals
• The National Institutes of Health

In March of 2014, the CMTA entered an alliance with Ionis Pharmaceuticals (Ionis), a leading company in the development of Anti-Sense-Oligonucleotide (ASO) therapies. ASOs are short synthetic pieces of chemically modified nucleic acids (DNA or RNA) designed to bind to the RNA that codes for a protein. Once the ASO binds to the RNA it causes the destruction of the RNA by cellular enzymes, effectively leading to a decrease in the amount of targeted protein that is expressed. Ionis had previously demonstrated the ability to deliver an ASO to peripheral nerves and wanted to work with the CMTA to design a therapy that would decrease PMP22 protein levels in CMT1A patients. Specific ASOs were designed which proved effective in altering PMP22 RNA levels in two different rodent models of CMT1A.

In September 2014, the CMTA entered an alliance with Genzyme, a Sanofi company, to test their large libraries of molecules to identify those that dampen the known disease defect in CMT1A. A screening test capable of the automation required for this work was developed in a collaboration between the University of Wisconsin and the NIH. Following testing of close to 2 million molecules at Sanofi, a number of chemical classes were identified that suppress the overexpression of PMP22, a key protein implicated in the causation of CMT1A.

The global charcot-marie-tooth disease type I (CMT) market is segmented as follows:

By Type

• PXT3003 (Pharnext)
• ACE-083 (Acceleron)

By Therapy

• Physical Therapy
• Occupational Therapy
• Others PXT3003 (Pharnext)

By Region

• North America
  • The U.S.
  • Canada
• Europe
  • France
  • The UK
  • Spain
  • Germany
  • Italy
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • GCC
  • South Africa
  • Rest of Middle East & Africa