Proteins and peptides are an important class of biological substances. Polypeptide hormones like insulin are used in treating various diseases. Proteins and peptides enhance successful delivery of the drug to the desired site of action. Many proteins and peptides possess biological activity that makes them potent therapeutics. These potent peptides and proteins are designed and engineered in the lab to treat a variety of diseases that are administered orally and are termed as oral protein and peptide-based drugs.
Growing advancements in the field of biotechnology have resulted in the development of many novel therapeutic drugs. Among them, oral peptide & proteins have attracted considerable attention in the industry. Oral protein and peptides are widely being used in treating several diseases due to their high potency and specificity. Spurring demand for oral proteins and peptides in the treatment of chronic conditions such as cancer, hepatitis, diabetes, rheumatoid arthritis, and leukemia is driving the growth of global oral proteins and peptides market. Increasing the focus of key players on oral peptide drug discovery and ongoing research activities in active protein production is anticipated to encourage the growth of global oral proteins and peptides market in the coming years. In addition, the rising prevalence of chronic disorders, including diabetes, cancer, and other potent diseases are boosting the demand for oral proteins and peptides. Furthermore, the presence of large untapped market in emerging countries, consumers’ growing shift towards high-quality health care, and demand for effective drugs and technology are boosting the global oral protein and peptide market.
However, high drug manufacturing cost and large capital investment required for research and development activities of oral peptide drug may hinder the growth of this market. On the other hand, untapped market in developing countries, growing technological advancements in the development of new drugs, drugs under pipeline and clinical trial are expected to generate lucrative opportunities in the oral protein and peptides market in the forecast period.
By drug type, the global oral proteins and peptides market is divided into insulin, linaclotide, calcitonin, plecanatide, and octreotide. Among these products, insulin is expected to account for the largest share of the market. Linaclotide was the fastest growing segment in 2017 and is expected to grab a large share of total revenue in the coming years.
By application segment, the global oral proteins and peptides market is divided into diabetes, bone diseases, hormonal disorders, gastric & digestive disorder, and other. Diabetes was the leading application segment accounting for the largest revenue share in 2017. The outsized share of diabetes segment is primarily accredited to the high acceptance of oral insulin in diabetic population and relative increase in the prevalence of diabetes. The bone disease segment is expected to grow at the highest CAGR during the forecast period.
Based on geography, global oral proteins and peptides market is divided into five regions, North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. North America is expected to remain the dominant region in terms of revenue generation over the forecast period. Europe was the second largest market followed by the Asia Pacific. The Asia Pacific was the fastest growing market with the highest year on year growth rate. The Middle East and Africa and Latin America are expected to experience slow growth in the oral proteins and peptides market in the years to come.
Some of the key players in oral proteins and peptides market include Allergan Plc, Chiasma, Inc., Synthetic Biologics, Generex Biotechnology Corp., Proxima Concepts Limited (Diabetology Ltd.), Novo Nordisk A/S, and Tarsa Therapeutics Inc., Synergy Pharmaceuticals Inc., Sanofi S.A., Biocon Limited, F. Hoffmann-La Roche AG, AstraZeneca Plc., Hovione Limited, Novartis International AG, among others.
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