Single-Use Bioreactors Market Size, Share, Trends, Growth 2028

Single-Use Bioreactors Industry Perspective:

The global single-use bioreactors market size was worth USD 3,274.10 million in 2021 and is estimated to grow to USD 10,123.6 million by 2028, with a compound annual growth rate (CAGR) of approximately 20.70 percent over the forecast period.

The report analyzes the single-use bioreactors market’s drivers, restraints/challenges, and the effect they have on the demands during the projection period. In addition, the report explores emerging opportunities in the single-use bioreactors market.

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Single-Use Bioreactor Market: Overview

Single-use bioreactors (SUBs), also known as disposable bioreactors, use disposable bags instead of stainless steel or glass culture vessels. It is flexible, easy to install, and requires fewer utility requirements such as steam and water. It also reduces labor costs, minimizes the risk of cross-contamination, and eliminates cleaning process and verification issues. As a result, a wide range of applications can be found in contract research organizations (CROs) and contract manufacturing organizations (CMOs) around the world. Overall, disposable bioreactors are suitable for the production of bio pharmacy due to their high operational efficiency.

Recently, the endless efforts of companies to promote their products have proved to be very progressive. You can see working on the instant sensor system, design, agitation mechanism & film technology of disposable bioreactors. Increased acceptance of SUBs among small and medium-sized enterprises and start-ups, reduced automation complexity, ease of cultivating marine organisms, reduced energy & water consumption, growth of the biopharmaceutical market, technological advances in SUBs, and increased R & D in biopharmaceuticals are factors driving drive growth market.

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Covid-19 Impact:

Many biopharmaceutical companies are rapidly developing vaccines in response to the new coronavirus pandemic. The impact of the coronavirus crisis on supply chains, production, and delivery to customers has traditionally been manageable in the bioprocess solutions market. The decline in global pharmaceutical R & D spending and biopharmaceutical sales in 2020 due to the outbreak of COVID-19 will significantly impact the SUB market growth during the forecast period.

Key Insights

• The global single-use bioreactors market was worth around USD 3,274.10  million in 2021 and is estimated to grow to about USD 10,123.7 billion by 2028, with a compound annual growth rate (CAGR) of approximately 20.70 percent over the forecast period
• The benefits of cost savings in construction, operation, and cleaning are anticipated to drive market growth.
• SUB uses pre-sterilized bioprocess bags, reducing the additional cost and time associated with sterilization.
• The mammalian cell segment has the largest share. This may be due to the high penetration of these cells in developing biopharmaceutical therapies and the commercial success of recombinant proteins derived from mammalian cells.
• North America is estimated to have the largest market share due to the presence of key investment players and the established bio pharmacy industry in the region.

Single-Use Bioreactors Market: Growth Drivers

Increasing biopharmaceutical R&D help drive the market growth

The susceptibility of the elderly population group to various diseases along with the growing elderly population is driving the demand for bio pharmacies worldwide. In anticipation of this demand, global companies are focusing on biopharmaceutical R & D and manufacturing to develop products and scale production. The pharmacy industry invests an average of six times more R & D in sales than other manufacturing industries. In 2018, bio pharmacy companies invested (estimated) US $ 102 billion in R & D (Source: PhRMA). Disposable technology is an integral part of the bio pharmacy manufacturing process. They account for the majority of small and medium-sized bio pharmacy production, especially in clinical trials and R & D. Due to the advantages of disposable systems over traditional bio-manufacturing techniques, their adoption in biopharmaceutical research and development is increasing. Therefore, increased R & D spending is seen as a positive indicator of global single-use bioreactors market growth.

Single-Use Bioreactors Market: Restraints

Need for improved single-use sensors to hamper the market expansion

Reliable, accurate, and cost-effective sensor availability that meets SUB needs is one of the key challenges in the market. The sensors used in the SUB must be compatible with the existing SUB platform and manage the system without compromising the sterility of the material. Traditionally, the sensor was installed in the SUB system, but this method reduced the quality of the final product. Ideally, the sensor and SUB are shipped as a unit, and the sensor is pre-installed on the SUB to ensure sterilization of the container and sensor. However, due to leaching and extractability issues, the quality of available sensors does not meet GMP standards. This creates challenges when using SUBs, but there is room for improvement in this market segment. But with the development of more accurate and individual process sensors for various parameters (pH value, temperature, flow measurement, product quality), it can then be incorporated into a bioprocess workflow.

Single-Use Bioreactors Market: Opportunities

Emerging markets show opportunities for the global single-use bioreactors market growth

Emerging markets such as China, India, and Indonesia offer significant growth opportunities due to the high growth of their respective pharmaceutical and biopharmacy sectors due to less stringent regulatory guidelines, cheaper labor, and more skilled labor. Due to their cost advantage and skilled workforce, these countries have become hubs for bioprocess outsourcing. Developing countries show that disposable systems are growing fast. For example, many of China's new bioprocessing plants are expected to be built to meet both domestic demand and the desire to become a biopharmacy exporter. Chinese biopharmacy companies have also found that Chinese CMOs are more likely to accept the adoption of disposable technology than domestic biopharmaceutical developers/manufacturers. In 2018, Wuxi Biologics partnered with ABEC to install a 4,000L custom single-run disposable bioreactor at a new commercial production facility in Wuxi, China.

Single-Use Bioreactors Market: Report Scope

Single-Use Bioreactors Market: Segmentation

The global single-use bioreactors market is segregated on the basis of product, type, type of cell, molecule type, application, end user, and region.

By product, the market is divided into single-use bioreactor systems, single-use media bags, single-use filtration assemblies, and other products (single-use vessels, tubing and connectors, samplers, probes/sensors, and others). Among these, the single-use bioreactor systems segment dominates the market because single-use bioreactor systems offer benefits such as reduced capital investment, operating costs, and environmental footprint, facilitating the acceptance of these systems in bio pharmacy applications.

By type, the market is classified into stirred-tank SUBs, wave-induced SUBs, bubble-column SUBs, and Other SUBs (Hybrid bioreactors and SUBs with vertically perforated discs). Over the forecast period, the stirred-tank SUBs segment is expected to develop at the fastest rate due to the high demand for culturing aerobic microbial cultures and agitated SUBs. The agitation tank SUB promotes greater oxygen transfer and reduces engineering challenges such as heat removal, mass transfer, and faster agitation speeds.

Recent Developments

• In July 2021, BioCentriq and Pall Corporation collaborated in the clinical production of Zolgensma. This is an FDA-approved gene therapy using the iCELLis fixed-bed bioreactor.
• In February 2021, Wuxi Biologics launched a 36,000 liter bio production line with nine 4,000 liter disposable bioreactors.

Single-Use Bioreactors Market: Regional Landscape

The development of the manufacturing industry will help to grow North America region

During the forecast period, North America is likely to dominate the global single-use bioreactors market. The expansion of the region's manufacturing capacity is complementing the market's growth. For example, in September 2021, Thermo Fisher Scientific announced plans to build a new manufacturing facility for disposable bioprocessing products. The addition of the Nashville facility has expanded the global network of SUT manufacturing facilities. The presence of an established bio pharmacy industry and the presence of key players operating in the North American market.

Single-Use Bioreactors Market: Competitive Landscape

Some of the main competitors dominating the global single-use bioreactors market include-

• Thermo Fisher Scientific
• Danaher Corporation
• Merck KGaA
• Getinge AB
• Eppendorf AG
• CESCO Bioengineering
• Cellexus
• PBS Biotech Inc
• Distek Inc
• ABEC
• Able Corporation & Biott Corporation
• G&G Technologies Inc
• Solida Biotech GmBH
• Stobbe Pharma
• Celltainer Biotech BV
• Meissner Filtration Products Inc.
• bbi-biotech GmBH
• ENDEL ENGIE (France)
• OmniBRx biotechnologies
• New Horizon Biotechnology Inc
• Satake Chemical Equipment Mfg., Ltd
• Sartorius Stedim Biotech
• GPC Bio
• Cell culture company
• Aptus bioreactors

The global single-use bioreactors market is segmented as follows:

By Product

• Single-use Bioreactor Systems
• Single-use Media Bags
• Single-use Filtration Assemblies
• Other Products (Single-use vessels, tubing and connectors, samplers, and probes/sensor, and others)

By Type

• Stirred-tank SUBs
• Wave-induced SUBs
• Bubble-column SUBs
• Other SUBs (Hybrid bioreactors and SUBs with vertically perforated discs)

By Type of Cell

• Mammalian Cells
• Bacterial Cells
• Yeast Cells
• Other Cells (Insect and plant cells)

By Molecular type

• Monoclonal Antibodies
• Vaccines
• Gene-modified cells
• Stem Cells
• Other Molecules (Recombinant proteins including growth factors & interferons, antisense, RNA interference, and others)

By Application

• Research and Development (R&D)
• Process Development
• Bioproduction

By End User

• Pharmaceutical & Biopharmaceutical Companies
• CROs & CMOs
• Academic Research Institutes

By Region

• North America
  • The U.S.
  • Canada
• Europe
  • France 
  • The UK
  • Spain
  • Germany
  • Italy
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Southeast Asia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • GCC
  • South Africa
  • Rest of Middle East & Africa